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Leib­niz-Insti­tut für Natur­stoff-For­schung und Infek­ti­ons­bio­lo­gie e.V.-Hans-Knöll-Insti­tut- - Bio Pilot Plant

The sci­en­tists at the Leib­niz-HKI carry out rese­arch into natu­ral pro­ducts from micro-orga­nisms and into the infec­tion bio­logy of patho­ge­nic fungi. Novel dis­co­ve­ries of natu­ral pro­ducts are inves­ti­ga­ted for their bio­lo­gi­cal activity and modi­fied pur­po­se­fully for pos­si­ble drug app­li­ca­ti­ons. In this con­text, the insti­tute has been main­tai­ning a rich tra­di­tion in Jena brin­ging in cut­ting-edge approa­ches to solu­ti­ons and rese­arch methods bey­ond that.

The Leib­niz-HKI is firmly inte­gra­ted into the most important Thu­rin­gian rese­arch centre, the Beu­ten­berg Cam­pus Jena. Bey­ond the close cor­po­ra­tion with the neigh­bour­hood insti­tu­tes, we col­la­bo­rate inten­si­vely with the Fried­rich-Schil­ler-Uni­ver­sity Jena, the Jena Uni­ver­sity Hos­pi­tal and the Uni­ver­sity of App­lied Sci­en­ces Ernst-Abbe in Jena. This lea­ves a link in nume­rous joint rese­arch pro­jects and a strong com­mit­ment of our staff to aca­de­mic tea­ching.

Sci­entific or tech­nical assist­ant (f/div/m) in Syn­thetic Bio­logy or Bio­tech­no­logy

for one year ini­tially.

Working field:

Research Areas: Molecu­lar Bio­logy, Bio­chem­istry, Bio­tech­no­logy, Dic­ty­ostelium discoideum

This pro­ject is part of a Fed­eral Min­istry for Edu­ca­tion and Research (BMBF) fun­ded research pro­ject which aims to develop the social amoeba Dic­ty­ostelium discoideum into a pro­duc­tion plat­form for sec­ond­ary meta­bol­ites of phar­ma­ceut­ical import­ance.

The field of study:

The suc­cess­ful can­did­ate will assist in the con­struc­tion of multi-gene expres­sion plas­mids and the estab­lish­ment of CRISPR/Cas tools for strain engin­eer­ing of the social amoeba Dic­ty­ostelium discoideum and will help to develop meth­ods to meas­ure and enhance the pro­duc­tion of het­ero­log­ous sec­ond­ary meta­bol­ites.

The main top­ics of the pro­ject may include:
  • Meta­bolic engin­eer­ing of D. discoideum to enhance the pro­duc­tion of bio­chem­ical pre­curs­ors for poly­ketide pro­duc­tion
  • High-through­put cul­tiv­a­tions, auto­mated screen­ing and pro­cessing of pro­duc­tion strains of D. discoideum

Requirements:

  • A bach­elor or mas­ter degree in molecu­lar bio­logy, bio­chem­istry, micro­bi­o­logy, bio­tech­no­logy or related dis­cip­line. Can­did­ates about to obtain their degree are wel­come to apply.
  • A basic exper­i­mental back­ground in molecu­lar clon­ing and micro­bi­o­logy.
  • The can­did­ate should be highly inter­ested in applied, trans­la­tional research and able to work in an inter­na­tional, inter­dis­cip­lin­ary research team.

What we offer:

The suc­cess­ful can­did­ate will be part of the ProD­ICAN research pro­ject led by Prof. Dr. Falk Hill­mann. The aim of the group is to con­duct innov­at­ive, cut­ting-edge research on amoe­bae as a new host organ­ism for the pro­duc­tion of plant-derived nat­ural products. The Leib­niz-HKI is embed­ded in the out­stand­ing sci­entific envir­on­ment of the Beu­ten­berg Cam­pus provid­ing state-of-the-art research facil­it­ies and a highly integ­rat­ive net­work of life sci­ence groups. We offer a mul­ti­fa­ceted sci­entific pro­ject with excel­lent tech­nical facil­it­ies, a place in a dynamic, com­mit­ted team, as well as strong sci­entific col­lab­or­a­tions.

Salary is paid accord­ing to Ger­man TV-L (salary agree­ment for pub­lic ser­vice employ­ees). As an equal oppor­tun­ity employer, the Leib­niz-HKI is com­mit­ted to increas­ing the per­cent­age of female sci­ent­ists and there­fore espe­cially encour­ages them to apply.

How to apply:

Prof. Dr. Falk Hill­mann | +49 3641 532 1445 | career@leibniz-hki.de
Dr. Johann E. Kufs | +49 3641 532 1732 | career@leibniz-hki.de

Com­plete applic­a­tions in Ger­man or Eng­lish should include a cover let­ter, a CV, a brief state­ment of research exper­i­ences, and should be sub­mit­ted via the Leib­niz-HKI online applic­a­tion sys­tem. The dead­line for the advert­ise­ment is Octo­ber 15, 2022, but applic­a­tions will be reviewed on a rolling basis.